Endocrine Abstracts

Introduction: Diabetes mellitus (DM) may cause male infertility acting with pre-testicular, testicular and post-testicular mechanism.Aim: To evaluate the presence of male infertility and the mechanisms of sperm damage in diabetic patients in childbearing age.Patients and methods: Thirty-four patients with DM1, 55 with DM2 and 100 healthy fertile men (controls) were enrolled. Diabetic patients were further divided into three groups ...

Introduction: Treatment of adrenal insufficiency (AI) in the last years has been object of important changes due to the development of a dual-release preparation of hydrocortisone (Plenadren®). Hydrocortisone dual-release therapy contemplates a once-daily tablet that allows more closely mimicking the physiological circadian rhythm cortisol, thus avoiding overexposure.Objective: The aim of the study was to value effects of Plenadren administration on...

Importance: Early-onset androgenetic alopecia (AGA) has been suggested as a phenotypic sign of the male polycystic ovary syndrome (PCOS)-equivalent since men with this feature have a PCOS-like hormonal pattern. No study has evaluated the gonadal function of these men.Objective: To study the gonadal function of men with early-onset AGA and to identify suggestive criteria of male PCOS-equivalent.Design: This case-control study was co...

Over the last two years, COVID-19 outbreak and lockdown have exerted a remarkable psychological burden in the general population. Such an impact is supposed to be even worse in acromegaly, known to induce a severe psychological impairment due to its somatic disfigurements and systemic comorbidities. The current observational study aimed at investigating the impact of COVID-19 outbreak and lockdown on psychological health in acromegalic patients as compared to non-acromegalic h...

Objective: The management of male idiopathic infertility is challenging. The Italian Medicines Agency (AIFA) note 74 regulates the empirical administration of follicle-stimulating hormone (FSH), although its application in clinical practice remain conflicting. The aim was to explore the management of male idiopathic infertility and to assess the actual use of FSH.Methods: A multicenter longitudinal prospective observational study (open-registry), involvi...